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A comprehensive study has identified distinct oral microbiome and metabolome profiles in relapsing-remitting multiple sclerosis patients. Researchers found decreased beneficial bacteria and significantly lower hypotaurine levels, potentially opening new avenues for diagnosis and treatment. The findings suggest the oral environment may play a crucial role in MS pathobiology.

Significant Oral Microbiome Differences Identified

People with relapsing-remitting multiple sclerosis (RRMS) exhibit distinct oral microbiome compositions compared to healthy individuals, according to a recent study published in npj Biofilms and Microbiomes. The research, which analyzed 50 RRMS patients and 50 healthy controls through shotgun metagenomic sequencing and untargeted metabolomics, revealed numerous previously unidentified salivary alterations that sources indicate could provide new diagnostic and therapeutic targets.